Darapladib

Catalog #: 6755 Datasheet / COA / SDS

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6755/10

Darapladib | CAS No. 356057-34-6 | Phospholipase Inhibitors

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Description: Potent lp-PLA2 inhibitor

Chemical Name: N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide

Purity: ≥98%

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Biological Activity

Darapladib is a potent lipoprotein-associated phospholipase A₂ (lp-PLA₂) inhibitor (IC₅₀ = 5 nM in whole human plasma).

Technical Data

M.Wt:

666.77

Formula:

C₃₆H₃₈F₄N₄O₂S

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

356057-34-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A₂.
Blackie et al.
Bioorg.Med.Chem.Lett., 2003;13:1067

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