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DCG IV

Catalog #: 0975
33 Citations Datasheet / COA / SDS
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0975/1
DCG IV | CAS No. 147782-19-2 | Group II mGluR Agonists
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Description: Highly potent group II mGlu agonist; also NMDA agonist

Chemical Name: (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine

Purity: ≥98%

Product Details
Citations (33)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

DCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors.

Technical Data

M.Wt:
203.15
Formula:
C7H9NO6
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
147782-19-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Suntory Ltd.

Background References

  1. Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine.

    Mol Brain, 2011;4(0):12.
  2. The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
    Siegert S, Seo J, Kwon E, Rudenko A, Cho S, Wang W, Flood Z, Martorell A, Ericsson M, Mungenast A, Tsai L
    Nat Neurosci, 2015;18(7):1008-16.
  3. Interplay between synchronization of multivesicular release and recruitment of additional release sites support short-term facilitation at hippocampal mossy fiber to CA3 pyramidal cells synapses.
    Chamberland S, Evstratova A, Toth K
    J Neurosci, 2014;34(33):11032-47.
  4. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  5. Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
    Brabet et al.
    Neuropharmacology, 1998;37:1043
  6. Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes.
    Cartmell et al.
    Br.J.Pharmacol., 1998;123:497
  7. A novel metabotropic receptor agonist: marked depression of monosynaptic excitation in the isolated rat spinal cord.
    Ishida et al.
    Br.J.Pharmacol., 1993;109:1169
  8. Synthesis of L-2-(2,3-dicarboxycyclopropyl)-glycines. Novel conformationally restricted glutamate analogues.
    Ohfune et al.
    Bioorg.Med.Chem.Lett., 1993;3:15

Product Datasheets

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Citations for DCG IV

The citations listed below are publications that use Tocris products. Selected citations for DCG IV include:

33 Citations: Showing 1 - 10

  1. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
    Authors: Hashimotodani Et al.
    Neuron  2017;95:928
  2. Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall.
    Authors: Sun Et al.
    Neuron  2017;95:656
  3. Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
    Authors: Scholler
    Nat Commun  2017;8(1):1967
  4. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  5. Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
    Authors: Miguel Angel Garcia-Bereguiain Et al.
    The Journal of Neuroscience  2016;6:7268
  6. DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.
    Authors: Suberbielle Et al.
    Acta Neuropathol Commun  2015;6:8897
  7. The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus.
    Authors: Martin Et al.
    Elife  2015;4
  8. Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation.
    Authors: Decker Et al.
    Cell Rep  2015;3:23
  9. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
    Authors: Galván Et al.
    Neuroscience  2015;290:332
  10. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
    Authors: Ben-Simon Et al.
    J Neurosci  2015;12:396
  11. Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.
    Authors: Maurin Et al.
    PLoS One  2014;9:e87605
  12. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
    Authors: Yin Et al.
    J Neurosci  2014;34:79
  13. Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.
    Authors: Kaeser-Woo Et al.
    J Neurosci  2013;33:9769
  14. Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus.
    Authors: Skucas Et al.
    J Neurosci  2013;33:2338
  15. Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.
    Authors: Vivar Et al.
    Eur J Neurosci  2012;35:76
  16. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep  2012;2:285
  17. Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
    Authors: Taman and Ribeiro
    PLoS One  2011;6:e27119
  18. Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.
    Authors: Prickett Et al.
    Nat Genet  2011;43:1119
  19. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
    Authors: Sydow Et al.
    J Neurosci  2011;31:2511
  20. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
    Authors: Straub Et al.
    Nat Neurosci  2011;14:866
  21. Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
    Authors: Ster Et al.
    Proc Natl Acad Sci U S A  2011;108:9993
  22. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(β)42 from isolated intact nerve terminals.
    Authors: Kim Et al.
    Nat Commun  2010;30:3870
  23. Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
    Authors: Galván Et al.
    J Neurosci  2010;30:2844
  24. Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance.
    Authors: Torborg Et al.
    J Neurosci  2010;30:15628
  25. Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism.
    Authors: Hagena and Manahan-Vaughan
    Cereb Cortex  2010;20:1121
  26. Glutamatergic inhibition in sensory neocortex.
    Authors: Lee and Sherman
    Cereb Cortex  2009;19:2281
  27. Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway.
    Authors: Bagayogo and Dreyfus
    ASN Neuro  2009;1
  28. Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
    Authors: Kim and Tsien
    Neuron  2008;58:925
  29. Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.
    Authors: Suh Et al.
    Neuron  2008;58:736
  30. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus.
    Authors: Chiu and Castillo
    Neuropharmacology  2008;54:68
  31. BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A  2008;28:8677
  32. The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.
    Authors: Andrieux Et al.
    Genes Dev  2002;16:2350
  33. Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism.
    Authors: Yeckel Et al.
    Nat Neurosci  1999;2:625

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