Devazepide
Chemical Name: N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
Purity: ≥99%
Biological Activity
Devazepide is a potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence.
Wen D, Ma CL, Zhang YJ, Meng YX, Ni ZY, Li SJ, Cong B
BMC Neurosci, 2012;13(0):63. -
MetF. activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Duca et al.
Nat.Med., 2015;21:506 -
Effects of intracerebroventricular administration of the CCK1 receptor antagonist devazepide on food intake in rats.
Ebenezer
Eur.J.Pharmacol., 2002;441:79 -
Effects of peripheral CCK receptor blockade on food intake in rats.
Reidelberger et al.
Am.J.Physiol.Reg.Integr.Comp.Physiol., 2003;285:R429 -
Increased food intake and CCK receptor antagonists: beyond abdominal vagal afferents.
Ritter
Am.J.Physiol.Reg.Integr.Comp.Physiol., 2004;286:R991
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Citations for Devazepide
The citations listed below are publications that use Tocris products. Selected citations for Devazepide include:
9 Citations: Showing 1 - 9
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Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity.
Authors: Argueta Et al.
Front Physiol 2019;10:704
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Lactobacillus gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose Homeostasis.
Authors: Bauer Et al.
Cell Metab 2018;27:572
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Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.
Authors: D'Agostino Et al.
BMC Neurosci 2016;5
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Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages.
Authors: Saia Et al.
Mediators Inflamm 2014;2014:896029
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Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats.
Authors: Blouet and Schwartz
PLoS One 2012;7:e51898
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Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.
Authors: Blevins Et al.
Am J Physiol Regul Integr Comp Physiol 2012;303:R1231
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Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular mor. dependence.
Authors: Wen Et al.
Front Mol Neurosci 2012;13:63
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Ongoing ingestive behavior is rapidly suppressed by a preabsorptive, intestinal "bitter taste" cue.
Authors: Schier Et al.
Am J Physiol Regul Integr Comp Physiol 2011;301:R1557
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Intestinal cholecystokinin controls glucose production through a neuronal network.
Authors: Cheung Et al.
Cell Metab 2009;10:99
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