Home / Adrenergic alpha-2 Receptor Agonists / Dexmedetomidine hydrochloride

Dexmedetomidine hydrochloride

Catalog #: 2749
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2749/10
2749/50
Dexmedetomidine hydrochloride | CAS No. 145108-58-3 | Adrenergic alpha-2 Receptor Agonists
1 Image
Description: Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
Alternative Names: d-Medetomidine hydrochloride

Chemical Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride

Purity: ≥98%

Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Dexmedetomidine hydrochloride is an active isomer of medetomidine, a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than Clonidine (Cat. No. 0690) and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Racemate also available.

Technical Data

M.Wt:
236.74
Formula:
C13H16N2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
145108-58-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Endophilin marks and controls a clathrin-independent endocytic pathway.
    Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
    Nature, 2015;517(7535):460-5.
  2. Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist.
    Virtanen et al.
    Eur.J.Pharmacol., 1988;150:9
  3. Antinociceptive properties of intrathecal dexmedetom. in rats.
    Fisher et al.
    Eur.J.Pharmacol., 1991;192:221
  4. Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects.
    Scheinin et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 1989;13:635

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Dexmedetomidine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Dexmedetomidine hydrochloride include:

7 Citations: Showing 1 - 7

  1. Induction of Non-Apoptotic Cell Death by Adrenergic Agonists in Human Oral Squamous Cell Carcinoma Cell Lines.
    Authors: Uchida Et al.
    Anticancer Res  2019;39:3519
  2. Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation
    Authors: Ma Et al.
    Curr Biol  2019;29:3315
  3. σ1 receptor ligands control a switch between passive and active threat responses.
    Authors: Rennekamp Et al.
    Nat Chem Biol  2016;12:552
  4. Corneal Anesthesia With Site 1 Sodium Channel Blockers and dexmedetom.
    Authors: McAlvin Et al.
    J Inflamm (Lond)  2015;56:3820
  5. Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat.
    Authors: Garrity Et al.
    Invest Ophthalmol Vis Sci  2015;38:73
  6. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine.
    Authors: Gozzi Et al.
    Neuropsychopharmacology  2013;38:2120
  7. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function.
    Authors: Yuki Et al.
    Anesth Analg  2011;112:830

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Dexmedetomidine hydrochloride

There are currently no reviews for this product. Be the first to review Dexmedetomidine hydrochloride and earn rewards!

Have you used Dexmedetomidine hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.