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DFMO

Catalog #: 2761
1 Citation Datasheet / COA / SDS
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2761/10
2761/50
DFMO | CAS No. 68278-23-9 | Decarboxylase Inhibitors
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Description: Ornithine decarboxylase inhibitor
Alternative Names: Eflornithine

Chemical Name: DL-2-(Difluoromethyl)-ornithine hydrochloride

Product Details
Citations (1)
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Biological Activity

DFMO is an irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.

Technical Data

M.Wt:
218.63
Formula:
C6H12F2N2O2.HCl
Solubility:
Soluble to 75 mM in water
Storage:
Desiccate at RT
CAS No:
68278-23-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Promotion of homology-directed DNA repair by polyamines
    CY Lee, GC Su, WY Huang, MY Ko, HY Yeh, GD Chang, SJ Lin, P Chi
    Nat Commun, 2019;10(1):65.
  2. Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.
    Wu et al.
    Biochem.J., 2012;442:693
  3. Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent.
    Raul
    Biochem.Soc.Trans., 2007;35:353
  4. Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase.
    Carrillo et al.
    Biochem.Biophys.Res.Comm., 2000;279:663

Product Datasheets

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Citation for DFMO

The citations listed below are publications that use Tocris products. Selected citations for DFMO include:

1 Citation: Showing 1 - 1

  1. Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation.
    Authors: Machado Et al.
    Cell Stem Cell  2021;28:1

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