Digoxin
Chemical Name: 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Purity: ≥98%
Biological Activity
Digoxin is an inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.17 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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HIF1? regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia
P Wang, C Lan, S Xiong, X Zhao, Y Shan, R Hu, W Wan, S Yu, B Liao, G Li, J Wang, D Zou, B Chen, H Feng, N Wu
Oncotarget, 2017;8(17):28074-28092. -
Endogenous digitalis-like factors. An historical overview.
Buckalew
Front.Biosci., 2005;10:2325 -
Digoxin in the management of cardiovascular disorders.
Gheorghiade et al.
Circulation, 2004;109:2959 -
Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels.
Sjogren et al.
Mol.Pharmacol., 2012;82:500
Product Datasheets
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Citations for Digoxin
The citations listed below are publications that use Tocris products. Selected citations for Digoxin include:
5 Citations: Showing 1 - 5
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Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice.
Authors: Jing Et al.
J Clin Invest 2023;
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The cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles.
Authors: Rob Et al.
Sci Rep 2020;10:5258
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Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons.
Authors: Ellen A Et al.
J Neurosci 2019;39:7086-7101
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HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia.
Authors: Wang Et al.
Oncotarget 2017;8:28074
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HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels.
Authors: Wang Et al.
Sci Rep 2017;7:7965
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