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Dofetilide

Catalog #: 3757
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3757/5
3757/25
Dofetilide | CAS No. 115256-11-6 | Voltage-gated Potassium Channel Blockers
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Description: KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
Alternative Names: Tikosyn,UK 68798

Chemical Name: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Dofetilide is a selective potassium channel blocker. Blocks KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Displays class III antiarrhythmic properties.

Technical Data

M.Wt:
441.56
Formula:
C19H27N3O5S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
115256-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.
    Gwilt et al.
    J.Pharmacol.Exp.Ther., 1991;256:318
  2. [3H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel.
    Finlayson et al.
    Eur.J.Pharmacol., 2001;412:203
  3. Voltage- and time-dependent block of delayed K+ current in cardiac myocytes by dofet.
    Carmeliet
    J.Pharmacol.Exp.Ther., 1992;262:809
  4. Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses.
    Helena Carstensen, Line Kjær, Maria Mathilde Haugaard, Mette Flethøj, Eva Zander Hesselkil, Jørgen K Kanters, Steen Pehrson, Rikke Buhl, Thomas Jespersen
    Journal of Cardiovascular Pharmacology, 2018;0(0):1533-4023.

Product Datasheets

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Citations for Dofetilide

The citations listed below are publications that use Tocris products. Selected citations for Dofetilide include:

5 Citations: Showing 1 - 5

  1. Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity.
    Authors: Mark Et al.
    Cell Stem Cell  2020;27:813-821.e6
  2. Effects of UK 68798 and RS 43285 on atrial fibrillatory rate in a horse model of acutely induced atrial fibrillation.
    Authors: Carstensen Et al.
    J Cardiovasc Electrophysiol  2019;30:596
  3. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
    Authors: McKeithan Et al.
    Front Physiol  2017;8:766
  4. Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor.
    Authors: Roger Et al.
    Am J Obstet Gynecol  2017;216:283.e1-283.e14
  5. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
    Authors: Bhave Et al.
    Mol Pharmacol  2011;79:42

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