DPNI-caged-GABA

Name: DPNI-caged-GABA
Brand: Tocris Bioscience
SKU: 2991

Catalog #: 2991
2 Citations Datasheet / COA / SDS

Discontinued Product

2991 has been discontinued.

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DPNI-caged-GABA | CAS No. 927866-58-8 | GABA-A Receptor Agonists

1 Image

Description: Nitroindoline-caged GABA

Chemical Name: 1-(4-Aminobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline

Purity: ≥98%

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Product Details

Citations (2)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Nitroindoline-caged GABA (Cat.No. 0344) with similar photochemical properties to MNI-glutamate (Cat. No. 1490); for example, the same quantum yield (0.085). Highly water soluble; exhibits fast photorelease that is efficient at near-UV and 405 nm wavelengths.

Technical Data

M.Wt:

499.3

Formula:

C₁₅H₂₃N₃O₁₂P₂

Solubility:

Soluble to 2 mM in water with gentle warming

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

927866-58-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold under licence from the Medical Research Council.

Background References

Synthesis and photochemistry of photolabile derivatives of gamma-aminobutyric acid for chemical kinetic investigations of the gamma-aminobutyric acid receptor in the millisecond time region.
Wieboldt et al.
Biochemistry, 1994;33:1526
Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ.
Trigo et al.
J.Neurosci.Meths., 2009;181:159
Presynaptic miniature GABAergic currents in developing interneurons.
Trigo
Neuron, 2010;66:235

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for DPNI-caged-GABA

The citations listed below are publications that use Tocris products. Selected citations for DPNI-caged-GABA include:

2 Citations: Showing 1 - 2

KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Authors: Spoljaric Et al.
Cell Rep 2019;26:1073
Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination.
Authors: Nunez-Parra Et al.
PLoS One 2013;110:14777

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