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Dynarrestin

Catalog #: 6526
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6526/5
Dynarrestin | CAS No. 2222768-84-3 | Hedgehog Signaling Inhibitors
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Description: Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein

Chemical Name: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.

Technical Data

M.Wt:
431.5
Formula:
C22H23F2N3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2222768-84-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dynarrestin, a novel inhibitor or cytoplasmic dynein.
    Höing et al.
    Cell Chem.Biol., 2018;25:357

Product Datasheets

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Citations for Dynarrestin

The citations listed below are publications that use Tocris products. Selected citations for Dynarrestin include:

3 Citations: Showing 1 - 3

  1. Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix.
    Authors: Sandra L Et al.
    iScience  2023;26:105965
  2. Mechanical Counterbalance of Kinesin and Dynein Motors in a Microtubular Network Regulates Cell Mechanics, 3D Architecture, and Mechanosensing.
    Authors: Jian Et al.
    ACS Nano  2021;15:17528-17548
  3. Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles.
    Authors: Charles E Et al.
    J Virol  2019;93

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