EGCG
Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
Purity: ≥98%
Biological Activity
EGCG is a β-secretase (BACE1) inhibitor (IC50 = 1.6 μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids.
Lee et al.
Mol.Pharmacol., 2005;68:1018 -
Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.
Sinha et al.
ACS Chem.Neurosci., 2012;3:451 -
EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer.
Shankar et al.
Front.Biosci., 2008;13:440 -
Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.
Yang et al.
Cancer Res., 2009;69:7986 -
Green tea catechins as a BACE1 (β-secretase) inhibitor.
Jeon et al.
Bioorg.Med.Chem.Lett., 2003;13:3905 -
Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells.
Ahmad et al.
Ach.Biochem.Biophys., 2000;376:338
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for EGCG
The citations listed below are publications that use Tocris products. Selected citations for EGCG include:
11 Citations: Showing 1 - 10
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Evaluation of Glutaminolysis in T Cells.
Authors: Warren Et al.
Curr Protoc 2022;2:e540
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EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses.
Authors: Michael F Et al.
Pharmaceuticals (Basel) 2021;14
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Distinguishing the Effect on the Rate and Yield of Aβ42 Aggregation by Green Tea Polyphenol EGCG.
Authors: Zhefeng Et al.
ACS Omega 2020;5:21497-21505
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The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation.
Authors: Rainer Et al.
Int J Mol Sci 2020;21
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The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo.
Authors: C Et al.
Neurobiol Dis 2020;138:104791
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Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.
Authors: Daniels Et al.
Sci Rep 2019;9:2937
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The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG.
Authors: Tomas Et al.
Biomolecules 2019;9
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Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism.
Authors: Xue Et al.
R Soc Open Sci 2019;6:190179
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Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine.
Authors: Wei Et al.
Nutrients 2019;11
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LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Authors: Kottakis Et al.
Nature 2016;539:390
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Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells.
Authors: Eom Et al.
Allergy Asthma Immunol Res 2015;48:461
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