EHNA hydrochloride
Chemical Name: erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride
Purity: ≥98%
Biological Activity
EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA.
Liu, Shuo, Dunwell, Thomas L, Pfeifer, Gerd P, Dunwell, Jim M, Ullah, Ihsan, Wang, Yinsheng
PLoS ONE, 2013;8(12):e84620. -
Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition.
Bessodes et al.
Biochem.Pharmacol., 1982;31:879 -
Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T-cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.
Michie et al.
Cell.Signal., 1996;8:97 -
Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl)adenine.
Podzuweit et al.
Cell.Signal., 1995;7:733
Product Datasheets
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Citations for EHNA hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for EHNA hydrochloride include:
11 Citations: Showing 1 - 10
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Physiology and effects of nucleosides in mice lacking all four adenosine receptors.
Authors: Xiao Et al.
PLoS Biol 2019;17:e3000161
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Comprehensive Assessment of Oxidatively Induced Modifications of DNA in a Rat Model of Human Wilson's Disease.
Authors: Yu Et al.
Mol Cell Proteomics 2016;15:810
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Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass
Authors: Davidson Et al.
PLoS One 2016;11:e0158981
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Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances.
Authors: Li Et al.
Am J Physiol Renal Physiol 2015;3:e00121
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Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA.
Authors: Liu Et al.
Nat Neurosci 2014;8:e84620
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Induction of 8,5'-cyclo-2'-deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents.
Authors: Guerrero Et al.
Chem Res Toxicol 2013;26:1361
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Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.
Authors: Prakasam Et al.
PLoS One 2012;303:F279
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Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices.
Authors: Lindquist
Neuroscience 2012;223:365
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Adenosine mediated desensitization of cAMP signaling enhances T-cell responses.
Authors: Yang Et al.
Eur J Immunol 2010;40:449
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Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats.
Authors: Takahashi Et al.
Br J Pharmacol 2010;161:1806
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Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate.
Authors: Uckert
J Urol 2001;166:2484
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