Enoximone
Chemical Name: 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one
Purity: ≥99%
Biological Activity
Enoximone is an inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, o
Jung et al.
J.Pharmacol.Exp.Ther., 2005;312:517 -
Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience.
Pacher and Stanek
Eur.J.Heart Fail., 1999;1:263 -
Effect of phosphodiesterase inhibitors on human arteries in vitro.
Vroom et al.
Br.J.Anaesth., 1996;76:122
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