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Entecavir

Catalog #: 6234 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6234/10
6234/50
Entecavir | CAS No. 142217-69-4 | RNA/DNA Polymerase Inhibitors
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Description: Potent and selective hepatitis B virus inhibitor
Alternative Names: BMS 200475,SQ 34676

Chemical Name: 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

Purity: ≥98%

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Biological Activity

Entecavir is a potent and selective hepatitis B virus reverse transcriptase inhibitor (EC50 = 3 nM); guanine analog. Inhibits hepatitis B virus replication in HepG2.2.15 cells. Displays selectively over HCMV, HSV-1, VZV, HIV and influenza (EC50 values are 15, 32, 30-60, >10 and >80 μM respectively). Orally bioavailable.

Technical Data

M.Wt:
277.28
Formula:
C12H15N5O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
142217-69-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
    Bisacchi et al.
    Bioorganic & Medicinal Chemistry Letters, 1997;7:127
  2. Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus.
    Innaimo et al.
    Antimicrob. Agents Chemother., 1997;41:1444

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