(±)-Epibatidine

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Melanopsin is highly resistant to light and chemical bleaching in vivo.
   Sexton TJ, Golczak M, Palczewski K
   J. Biol. Chem., 2012;287(25):20888-97.
2. Structural Analysis and Deletion Mutagenesis Define Regions of QUIVER/SLEEPLESS that Are Responsible for Interactions with Shaker-Type Potassium Channels and Nicotinic Acetylcholine Receptors.
   Wu M, Liu C, Joiner W
   PLoS ONE, 2016;11(2):e0148215.
3. Epibatidine, a potent analgesic and nicotinic agonist.
   Badio and Daly
   Mol.Pharmacol., 1994;45:563
4. Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors.
   Gerzarich et al.
   Mol.Pharmacol., 1995;48:774
5. Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain.
   Marks et al.
   J.Pharmacol.Exp.Ther., 1998;285:377
6. UB-165 implicates α4β2 nAChR in striatal DA release.
   Sharples et al.
   J.Neurosci., 2000;20:2783
7. Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity.
   Spande et al.
   J.Am.Chem.Soc., 1992;114:3475

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