Epiblastin A
Chemical Name: 6-(3-Chlorophenyl)-2,4,7-pteridinetriamine
Purity: ≥98%
Biological Activity
Epiblastin A is a CK1 inhibitor (IC50 values are 0.8, 3.7 and 3.8 μM for CK1δ, CK1ε and CK1α). Converts late-stage epiblast stem cells into germline-competent embryonic SC-like cells. Promotes activation and maintenance of the pluripotency network. Promotes ESC self-renewal at a concentration of 2 μM.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Epiblastin A induces reprogramming of epiblast stem cells Into embryonic stem cells by inhibition of casein kinase 1.
Ursu et al.
Cell Chem.Bio., 2016;23:494 -
Distinct signaling requirements for the establishment of ESC pluripotency in late-stage EpiSCs.
Illich et al.
Cell Rep., 2016;15:787
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