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ER 27319 maleate

Catalog #: 2471
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2471/10
2471/50
ER 27319 maleate | CAS No. 1204480-26-1 | Syk Kinase Inhibitors
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Description: Selective Syk kinase inhibitor

Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ER 27319 maleate is a selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.

Technical Data

M.Wt:
396.17
Formula:
C18H20N2O.C4H4O4
Solubility:
Soluble to 75 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
1204480-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Specific pathways mediating inflammasome activation by Candida parapsilosis
    A Tóth, E Zajta, K Csonka, C Vágvölgyi, MG Netea, A Gácser
    Sci Rep, 2017;7(0):43129.
  2. Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases.
    Luskova and Draber
    Curr.Pharm.Des., 2004;10:1727
  3. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk.
    Moriya et al.
    Proc.Natl.Acad.Sci.USA, 1997;94:12539

Product Datasheets

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Citations for ER 27319 maleate

The citations listed below are publications that use Tocris products. Selected citations for ER 27319 maleate include:

2 Citations: Showing 1 - 2

  1. Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells.
    Authors: Rycaj Et al.
    Oncotarget  2016;7:14220
  2. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.
    Authors: Ng Et al.
    Immunity  2008;29:807

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