Ex 26

Catalog #: 5833
4 Citations Datasheet / COA / SDS

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Ex 26 | CAS No. 1233332-37-0 | Sphingosine-1-phosphate Receptor Antagonists

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Description: Potent and selective S1P1 receptor antagonist

Chemical Name: 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid

Purity: ≥98%

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Product Details

Citations (4)

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Biological Activity

Ex 26 is a potent and selective S1P₁ receptor antagonist (IC₅₀ = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P₁ over S1P₂, S1P₃, S1P₄ and S1P₅. Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P₁ receptor expression. Reduces disease severity in mice with EAE. Increases IFN-α production in stimulated dendritic cells in vivo.

Technical Data

M.Wt:

494.98

Formula:

C₂₈H₂₈ClFN₂O₃

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1233332-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

S1PR₁-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell IF.-a autoamplification.
Teijaro et al.
Proc.Natl.Acad.Sci.U.S.A., 2016;113:1351
Sphingosine 1-phosphate receptor 1 (S1P₁) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P₁ antagonist.
Cahalan et al.
Mol.Pharmacol., 2013;83:316
S1P signalling differentially affects migration of peritoneal B cell populations in vitro and influences the production of intestinal IgA in vivo.
Kleinwort et al.
Int.J.Mol.Sci., 2018;19:E391

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Citations for Ex 26

The citations listed below are publications that use Tocris products. Selected citations for Ex 26 include:

4 Citations: Showing 1 - 4

Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.
Authors: Shikhar Et al.
Cell Rep 2022;41:111742
Fingolimod and Diabetic Retinopathy: A Drug Repurposing Study.
Authors: Paolo Et al.
Front Pharmacol 2021;12:718902
Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease.
Authors: Richard Et al.
MBio 2020;11
Biased S1PR1 Signaling in B Cells Subverts Responses to Homeostatic Chemokines, Severely Disorganizing Lymphoid Organ Architecture.
Authors: Il-Young Et al.
J Immunol 2019;203:2401-2414

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