Home / beta-Catenin Compounds / exo-IWR 1

exo-IWR 1

Catalog #: 3947 Datasheet / COA / SDS

Discontinued Product

3947 has been discontinued.
View all beta-Catenin Compounds products.
exo-IWR 1 | CAS No. 1127442-87-8 | beta-Catenin Compounds
1 Image
Description: Negative control for endo-IWR 1 (Cat. No. 3532)

Chemical Name: 4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

Purity: ≥99%

Product Details
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

exo-IWR 1 is a negative control for endo-IWR 1 25-fold less active than endo-IWR 1; exhibits decreased activity against the Wnt/β-catenin pathway.

Active Analog also available.

Technical Data

M.Wt:
409.44
Formula:
C25H19N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
1127442-87-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
    Lu et al.
    Bioorg.Med.Chem.Lett., 2009;19:3825
  2. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
    Chen et al.
    Nature Chem.Biol., 2008;5:100
  3. TAZ is required for lung alveolar epithelial cell differentiation after injury
    T Sun, Z Huang, H Zhang, C Posner, G Jia, TR Ramalingam, M Xu, HD Brightbill, JG Egen, A Dey, JR Arron
    JCI Insight, 2019;5(0):.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for exo-IWR 1

There are currently no reviews for this product. Be the first to review exo-IWR 1 and earn rewards!

Have you used exo-IWR 1?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.