Fasentin
Chemical Name: N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
Purity: ≥98%
Biological Activity
Fasentin is a GLUT1 and GLUT4 inhibitor (IC50 = 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC50 = 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors.
Schimmer et al.
Cancer.Res., 2006;66:2367 -
A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death.
Wood et al.
Mol.Cancer.Ther., 2008;7:3546 -
Anticancer agents interacting with membrane glucose transporters.
Granchi et al.
Med.Chem.Comm., 2016;7:1716
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