Flutamide
Chemical Name: 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide
Purity: ≥98%
Biological Activity
Flutamide is a non-steroidal antiandrogen; competitive antagonist of the androgen receptor. Blocks the biological activity of testosterone in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Flutamide. Mechanism of action of a new nonsteroidal antiandrogen.
Sufrin and Coffey
Invest.Urol., 1976;13:429 -
Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells.
Butcher et al.
Cancer Res., 2007;67:85 -
Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.
Foster et al.
Prostate, 2011;71:480
Product Datasheets
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Citations for Flutamide
The citations listed below are publications that use Tocris products. Selected citations for Flutamide include:
2 Citations: Showing 1 - 2
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The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge.
Authors: Luis-Miguel Et al.
J Neuroinflammation 2020;17:37
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Androgen Receptor-Mediated Regulation of Intracellular Calcium in Human Airway Smooth Muscle Cells.
Authors: Y S Et al.
Cell Physiol Biochem 2019;53:215-228
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