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Fluvastatin sodium

Catalog #: 3309
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3309/50
Fluvastatin sodium | CAS No. 93957-55-2 | HMG-CoA Reductase Inhibitors
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Description: Potent HMG-CoA reductase inhibitor

Chemical Name: (±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.

Technical Data

M.Wt:
433.45
Formula:
C24H25FNNaO4
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
93957-55-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Fluvastatin sodium

The citations listed below are publications that use Tocris products. Selected citations for Fluvastatin sodium include:

5 Citations: Showing 1 - 5

  1. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
    Authors: Park Et al.
    Nat Immunol  2016;17:914
  2. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
    Authors: Rojo-Arreola Et al.
    PLoS One  2014;9:e87594
  3. Fluvastatin suppresses native and recombinant human P2X4 receptor function.
    Authors: Li and Fountain
    Purinergic Signal  2012;8:311
  4. Studies on the antibacterial effects of STAT--in vitro and in vivo.
    Authors: Bergman Et al.
    PLoS One  2011;6:e24394
  5. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT.
    Authors: Vainio Et al.
    Am J Physiol Renal Physiol  2011;2:1176

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