FMF-04-159-R

Tocris Bioscience | Catalog # 7159

Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
Tocris Bioscience

Key Product Details

Description

Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
View all Cyclin-dependent Kinase Inhibitors »

Product Description

FMF-04-159-R is a potent inhibitor of CDK16 and CDK14 (IC50 values are 6 and 140 nM, respectively in kinase activity assay; IC50 = 563 nM for CDK14 in BRET assay). Also binds CDK2 (IC50 = 493 nM). Inhibition reversible upon compound wash-out. Control for FMF-04-159-2 (Cat. No. 7158).

Product Specifications for FMF-04-159-R

Molecular Weight

685.02

Formula

C28H32Cl3N7O5S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(1-((3-(4-(Dimethylamino)butanamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide

CAS Number

2741262-15-5

InChI Key

CPSBAEQKXVXCRQ-UHFFFAOYSA-N

SMILES

CN(CCCC(NC1=CC=CC(S(=O)(N2CCC(NC(C3=NNC=C3NC(C4=C(C=C(C=C4Cl)Cl)Cl)=O)=O)CC2)=O)=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 68.5 100
Ethanol 34.25 50

Preparing Stock Solutions for FMF-04-159-R

The following data is based on the product molecular weight 685.02.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.46 mL 7.30 mL 14.60 mL
5 mM 0.29 mL 1.46 mL 2.92 mL
10 mM 0.15 mL 0.73 mL 1.46 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for FMF-04-159-R

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FMF-04-159-R

For research use only

Related Research Areas

Cell Cycle
Intracellular Kinases

Customer Reviews for FMF-04-159-R

There are currently no reviews for this product. Be the first to review FMF-04-159-R and earn rewards!

Have you used FMF-04-159-R?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card