Galanthamine hydrobromide

Key Product Details

Product Description

Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC₅₀ = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Product Specifications for Galanthamine hydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Galanthamine hydrobromide

The following data is based on the product molecular weight 368.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.58 mL	67.88 mL	135.77 mL
1 mM	2.72 mL	13.58 mL	27.15 mL
2 mM	1.36 mL	6.79 mL	13.58 mL
10 mM	0.27 mL	1.36 mL	2.72 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Sweeney Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 1989 PMID: 2626444
• Samochocki Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 2003 PMID: 12649296
• Capsoni Nerve growth factor and galant. ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 2002 PMID: 12205295
• Harvey The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 1995 PMID: 8604434
• Arias Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 2004 PMID: 14654102

Product Documents for Galanthamine hydrobromide