Galiellalactone
Chemical Name: (4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one
Purity: ≥95%
Biological Activity
Galiellalactone is a STAT3 inhibitor. Irreversibly binds STAT3 and inhibits binding to DNA. Inhibits IL-6-dependent JAK/STAT signaling. Induces cell-cycle arrest in G2/M phase and apoptosis in androgen-insensitive prostate cancer cells via activation of ATM/ATR pathway. Also destabilizes microtubules and inhibits cell migration. Exhibits anticancer effects in a mouse tumor xenograft model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells.
Don-Doncow et al.
J.Biol.Chem., 2014;289:15969 -
Inhibition of interleukin-6 signaling by galiellalactone.
Weilder et al.
FEBS Lett., 2000;484:1 -
Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells.
Garcia et al.
Oncotarget, 2016;7:4490
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