Home / CCK2 Receptor Agonists / Gastrin I (human)

Gastrin I (human)

Catalog #: 3006
9 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3006/1
Gastrin I (human)
1 Image
Description: Selective CCK2 agonist

Purity: ≥95%

Product Details
Citations (9)
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Gastrin I (human) is an endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Gastrin I stimulates gastric acid secretion and has a mitogenic effect on gastric cells. Gastrin I stimulates gastric epithelial cell proliferation and histamine secretion (EC50 values are 6.2 pM and 0.014 nM, respectively). Gastrin I is also used in the culture of stomach, intestine and pancreas organoids. For more information about using Gastrin I in the generation of gastric organoids see the Human Gastric Organoid Culture Protocol.

Technical Data

M.Wt:
2098.22
Formula:
C97H124N20O31S
Sequence:
XGPWLEEEEEAYGWMDF

(Modifications: X = Glp, Phe-17 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 1% Ammonia with sonication
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
10047-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells
    T Kijima, H Nakagawa, M Shimonoson, PM Chandramou, T Hara, V Sahu, Y Kasagi, O Kikuchi, K Tanaka, V Giroux, AB Muir, KA Whelan, S Ohashi, S Naganuma, AJ Klein-Szan, Y Shinden, K Sasaki, I Omoto, Y Kita, M Muto, AJ Bass, JA Diehl, GG Ginsberg, Y Doki, M Mori, Y Uchikado, T Arigami, NG Avadhani, D Basu, AK Rustgi, S Natsugoe
    Cell Mol Gastroenterol Hepatol, 2019;7(1):73-91.
  2. International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors.
    Noble et al.
    Pharmacol.Rev., 1999;51:745
  3. CCK1 and CCK2 receptors regulate gastric pepsinogen secretion.
    Blandizzi et al.
    Eur.J.Pharmacol., 1999;373:71
  4. VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1
    MI Capurro, LK Greenfield, A Prashar, S Xia, M Abdullah, H Wong, XZ Zhong, N Bertaux-Sk, J Chakrabart, I Siddiqui, C O'Brien, X Dong, L Robinson, RM Peek, DJ Philpott, Y Zavros, M Helmrath, NL Jones
    Nat Microbiol, 2019;0(0):.
  5. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
    Bartfeld et al.
    Gastroenterology, 2015;148:126
  6. SnapShot: Growing Organoids from Stem Cells.
    Sato et al.
    Cell, 2015;161:1700
  7. Establishment of gastrointestinal epithelial organoids
    Mahe et al.
    Curr.Protoc. Mouse Biol., 2014;3:217

Product Datasheets

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Citations for Gastrin I (human)

The citations listed below are publications that use Tocris products. Selected citations for Gastrin I (human) include:

9 Citations: Showing 1 - 9

  1. Estrogen-related receptor alpha drives mitochondrial biogenesis and resistance to neoadjuvant chemoradiation in esophageal cancer.
    Authors: Dings Et al.
    Cell.Rep.Med.  2022;3:100802
  2. Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
    Authors: He Et al.
    Cell Stem Cell  2022;29:1333
  3. Snake venom gland organoids.
    Authors: Post Et al.
    Cell  2020;180:233
  4. Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease.
    Authors: Filippini Et al.
    Sci Rep  2019;9:12286
  5. IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
    Authors: Colomer Et al.
    Mol Cell  2019;75:669
  6. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
    Authors: Somerville Et al.
    Cell Rep  2018;25:1741
  7. Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
    Authors: Roe Et al.
    Cell  2017;170:875
  8. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
    Authors: Bartfeld Et al.
    Front Cell Neurosci  2015;148:126
  9. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
    Authors: Bartfeld Et al.
    Gastroenterology  2015;148:126

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Stimulation of pancreatic acinar cells
By Louise Reynolds on 06/06/2019
Species: Mouse

Used to stimulate pancreatic acinar cells to secrete digestive enzymes in vitro

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