Home / DNA, RNA and Protein Synthesis Inhibitors / Gemcitabine hydrochloride

Gemcitabine hydrochloride

Catalog #: 3259
14 Citations Datasheet / COA / SDS
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3259/10
3259/50
Gemcitabine hydrochloride | CAS No. 122111-03-9 | DNA, RNA and Protein Synthesis Inhibitors
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Description: DNA synthesis inhibitor

Chemical Name: (+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride

Purity: ≥99%

Product Details
Citations (14)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Gemcitabine hydrochloride is a deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo. Inhibits replication of MERS-CoV and SARS-CoV in vitro (EC50 values are 1.216 and 4.957 μM, respectively).

Technical Data

M.Wt:
299.66
Formula:
C9H11F2N3O4.HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
122111-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy.
    Saida Y, Watanabe S, Tanaka T, Baba J, Sato K, Shoji S, Igarashi N, Kondo R, Okajima M, Koshio J, Ichikawa K, Nozaki K, Ishikawa D, Koya T, Miura S, Tanaka J, Kagamu H, Yoshizawa H, Nakata K, Narita I
    J Immunol, 2015;195(2):726-35.
  2. DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.
    Zhang G, Schetter A, He P, Funamizu N, Gaedcke J, Ghadimi BM, Ried T, Hassan R, Yfantis HG, Lee DH, Lacy C, Maitra A, Hanna N, Alexander HR, Hussain SP
    PLoS ONE, 2012;7(2):e31507.
  3. Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism.
    Heinemann et al.
    Semin.Oncol., 1995;22:11
  4. Evaluation of the antitumor activity of gemcit. (2',2'-Difluoro-2'-deoxycytidine).
    Hertel et al.
    Cancer Res., 1990;50:4417
  5. Preclinical characteristics of gemcit.
    Plunkett et al.
    Anticancer Drugs, 1995;6:7
  6. Repurposing of clinically developed drugs for treatment of Middle East Respiratory Syndrome coronavirus infection.
    Dyall et al.
    Antimicrob.Agents Chemother., 2014;58:4885

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Citations for Gemcitabine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Gemcitabine hydrochloride include:

14 Citations: Showing 1 - 10

  1. Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.
    Authors: Marchetti Et al.
    J Med Chem  2018;61:2500
  2. SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.
    Authors: Viotti Et al.
    J Cell Biol  2018;217:763
  3. Plk1 inhibition enhances the efficacy of gemcit. in human pancreatic cancer.
    Authors: Li Et al.
    Cell Cycle  2016;15:711
  4. An automated fitting procedure and software for dose-response curves with multiphasic features.
    Authors: Veroli Et al.
    Mol Cancer Ther  2015;5:14701
  5. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.
    Authors: Truman Et al.
    J Proteomics  2015;112:285
  6. DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
    Authors: Dolman Et al.
    PLoS One  2015;10:e0145744
  7. Contrasting Effects of the Cytotoxic Anticancer Drug gemcit. and the EGFR Tyrosine Kinase Inhibitor gefi. on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells.
    Authors: Okita Et al.
    PLoS One  2015;10:e0139809
  8. Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity?
    Authors: Mayor-López Et al.
    Transl Oncol  2014;7:590
  9. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.
    Authors: Slee Et al.
    Mol Cancer Ther  2014;13:307
  10. BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcit.
    Authors: Jones Et al.
    PLoS One  2014;13:2412

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