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Gilteritinib

Catalog #: 7891 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7891/50
7891/10
Gilteritinib | CAS No. 1254053-43-4 | Flt-3/Flk-2
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Description: Potent FLT3 inhibitor; also potently inhibits AXL

Chemical Name: 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide

Purity: ≥98%

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Biological Activity

Gilteritinib is a potent Fms-like tyrosine kinase 3 (FLT3) and AXL inhibitor (IC50 = 0.29 nM and 0.73 nM, for FLT3 and AXL, respectively). In vivo, Gilteritinib reduces tumor growth and improves survival in xenograft and intra-bone marrow transplantation models of FLT3 mutated acute myeloid leukemia. Gilteritinib is orally bioavailable.

Technical Data

M.Wt:
552.71
Formula:
C29H44N8O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1254053-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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