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GlyH 101

Catalog #: 5485 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5485/10
5485/50
GlyH 101 | CAS No. 328541-79-3 | CFTR Blockers
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Description: Reversible, voltage-dependent CFTR chloride channel blocker

Chemical Name: N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide

Purity: ≥97%

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Biological Activity

GlyH 101 is a reversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.

Technical Data

M.Wt:
493.15
Formula:
C19H15Br2N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
328541-79-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells
    H Uchida, M Machida, T Miura, T Kawasaki, T Okazaki, K Sasaki, S Sakamoto, N Ohuchi, M Kasahara, A Umezawa, H Akutsu
    JCI Insight, 2017;2(1):e86492.
  2. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.
    Muanprasat et al.
    J.Gen.Physiol., 2004;124:125
  3. Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.
    Norimatsu et al.
    Mol.Pharmacol., 2012;82:1042

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