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GPR52 Comp-43

Catalog #: 7445 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7445/10
7445/50
GPR52 Comp-43 | CAS No. 1239987-91-7 | Orphan 7-TM Receptor Antagonists
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Description: GPR52 receptor antagonist

Chemical Name: (2E)-5-Phenyl-1-(2-thienyl)-2-penten-1-one

Purity: ≥98%

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Biological Activity

GPR52 Comp-43 is a GPR52 receptor antagonist (IC50 = 0.63 μM). The use of GPR52 Comp-43 in animal models of Huntington's Disease leads to degradation and reduction of soluble and aggregated mutant huntingtin protein in the striatum. It also reduces neuronal loss, promotes neuronal survival and improves motor functions in vivo. GPR52 Comp-43 is active in vitro and brain penetrant.

Technical Data

M.Wt:
242.34
Formula:
C15H14OS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1239987-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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