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GR 55562 dihydrochloride

Catalog #: 1054
9 Citations Datasheet / COA / SDS
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1054/50
GR 55562 dihydrochloride | CAS No. 159533-25-2 | 5-HT1B Receptor Antagonists
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Description: 5-HT1B antagonist

Chemical Name: 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride

Purity: ≥98%

Product Details
Citations (9)
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Biological Activity

GR 55562 dihydrochloride is a selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.

Technical Data

M.Wt:
448.39
Formula:
C23H25N3O2.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
159533-25-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline

Background References

  1. Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor.
    Tung S, Hardy A, Wheeler M, Belsham D
    Endocrinology, 2012;153(10):4862-73.
  2. Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia.
    Johansson S, Klitgaard Povlsen G, Edvinsson L
    PLoS ONE, 2012;7(7):e41852.
  3. Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery.
    MacLean et al.
    Br.J.Pharmacol., 1996;119:277
  4. The activity of 5-HT1D receptor ligands at cloned human 5-HT1Dα and 5-HT1Dβ receptors.
    Walsh et al.
    Eur.J.Pharmacol., 1995;287:79
  5. Use of GR55562, a selective 5-HT1D antagonist, to investigate 5-HT1D receptor subtypes mediating cerebral vasoconstriction.
    Connor et al.
    Cephalalgia, 1995;15:99

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Citations for GR 55562 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for GR 55562 dihydrochloride include:

9 Citations: Showing 1 - 9

  1. Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation.
    Authors: Zhou Et al.
    Behav Brain Res  2019;356:148
  2. Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands.
    Authors: Rataj Et al.
    Molecules  2018;23
  3. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
    Authors: Medrihan Et al.
    Neuron  2017;95:564
  4. Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia.
    Authors: Johansson Et al.
    PLoS One  2012;7:e41852
  5. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension.
    Authors: Morecroft Et al.
    Exp Eye Res  2010;85:593
  6. JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells.
    Authors: Wei Et al.
    Am J Physiol Lung Cell Mol Physiol  2010;298:L863
  7. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
    Authors: Guo and Rainnie
    Neuroscience  2010;165:1390
  8. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One  2009;4:e6453
  9. Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat.
    Authors: McDaid and Docherty
    Br J Pharmacol  2001;133:429

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