GR 55562 dihydrochloride

Tocris Bioscience | Catalog # 1054

5-HT1B antagonist
Tocris Bioscience

Key Product Details

Description

5-HT1B antagonist
View all 5-HT1B Receptor Antagonists »

Product Description

GR 55562 dihydrochloride is a selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for GR 55562 dihydrochloride

Molecular Weight

448.39

Formula

C23H25N3O2.2HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride

CAS Number

159533-25-2

PubChem ID

56972159

InChI Key

KBKWJHYQFQONBJ-UHFFFAOYSA-N

SMILES

Cl.Cl.CN(C)CCCC1=CC(=CC=C1O)C(=O)NC1=CC=C(C=C1)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for GR 55562 dihydrochloride

The following data is based on the product molecular weight 448.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.30 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for GR 55562 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GR 55562 dihydrochloride

For research use only

Citations for GR 55562 dihydrochloride

Customer Reviews for GR 55562 dihydrochloride (1)

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  • Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/03/2020
    100uM GR 55562
    GR 55562 dihydrochloride 1054

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