GR 73632

Catalog #: 1669
6 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1669/1

1 Image

Description: Potent and selective NK1 agonist

Purity: ≥95%

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Product Details

Citations (6)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

GR 73632 is a potent and selective tachykinin NK₁ receptor agonist (EC₅₀ = 2 nM in guinea pig vas deferens). Active in vivo. Intrathecal administration of GR 73632 in mice increases itch behavior.

Technical Data

M.Wt:

766.01

Formula:

C₄₀H₅₉N₇O₆S

Sequence:

FFPLM

(Modifications: Phe-1 = delta-Aminovaleryl-Phe, Leu-4 = (methyl)Leu, Met-5 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

133156-06-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from GlaxoSmithKline

Background References

Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation.
Hall and Morton
Ann.N.Y.Acad.Sci., 1991;632:404
GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK₁ receptor in the rat urinary bladder.
Meini et al.
Neuropeptides, 1995;28:99
Spinal actions of GR73632, a novel tachykinin NK₁ receptor agonist.
Sakurada et al.
Peptides, 1999;20:301

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for GR 73632

The citations listed below are publications that use Tocris products. Selected citations for GR 73632 include:

6 Citations: Showing 1 - 6

The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch.
Authors: Sheahan Et al.
J.Neurosci. 2020;40:8816
The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch.
Authors: Sheahan Et al.
J.Neurosci. 2020;40:1832
Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity.
Authors: León Et al.
Sci.Rep. 2016;6:19206
The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.
Authors: Navarro Et al.
Mol Psychiatry 2015;156:627
Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
Authors: Ruiz-Pino Et al.
Endocrinology 2015;156:576
TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.
Authors: Liu Et al.
FASEB J 2013;27:3549

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