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GSK 2833503A

Catalog #: 6497
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6497/10
GSK 2833503A | CAS No. 1366234-01-6 | TRPC Channel Blockers
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Description: Potent and selective TRPC6 and TRPC3 antagonist

Chemical Name: [2-[(4-Chloro-2-fluorophenyl)amino]-5-methyl-4-thiazolyl][(2S,3S)-2,3-dimethyl-1-piperidinyl]methanone

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cells in vitro and in cardiomyocytes.

Technical Data

M.Wt:
381.89
Formula:
C18H21ClFN3OS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1366234-01-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for GSK 2833503A

The citations listed below are publications that use Tocris products. Selected citations for GSK 2833503A include:

1 Citation: Showing 1 - 1

  1. Genetic- and diet-induced ω-3 fatty acid enrichment enhances TRPV4-mediated vasodilation in mice.
    Authors: Jonathan H Et al.
    Cell Rep  2022;40:111306

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