GsMTx4

Biological Activity

GsMTx4 is a spider venom peptide that selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels. GsMTx4 blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells. GsMTx4 also inhibits TACAN, a mechanosensitive ion channel involved in the pain response. GsMTx4 decreases the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells. GsMTx4 is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity in vivo in mice. GsMTx4 suppresses neurogenesis and enhances astrogenesis in human neural stem cells.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4.
   Bae et al.
   Biochemistry, 2011;50:6295
2. Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology.
   Bowman et al.
   Toxicon., 2007;49:249
3. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.
   Suchyna et al.
   J.Gen.Physiol., 2000;115:583
4. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain.
   Drew et al.
   PLoS One, 2007;2:e515
5. TACAN is an ion channel involved in sensing mechanical pain.
   Beaulieu-Laroche et al.
   Cell, 2020;

Product Datasheets