Home / Synthetic Metalloprotease Inhibitors / GW 280264X

GW 280264X

Catalog #: 7030
1 Citation Datasheet / COA / SDS
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7030/10
GW 280264X | CAS No. 866924-39-2 | Synthetic Metalloprotease Inhibitors
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Description: Potent ADAM10 and ADAM17 inhibitor

Chemical Name: Phenylmethyl N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GW 280264X is a potent ADAM (A Disintegrin and Metalloproteinase) 17 and ADAM10 inhibitor (IC50 values of 8 nM and 11.5 nM, respectively). It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells (IC50 = 1 μM in COS-7 and ECV-304 cells). GW 280264X treatment in mice significantly improves functional recovery after spinal cord injury.

Technical Data

M.Wt:
575.73
Formula:
C28H41N5O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
866924-39-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury
    Sommer D, Corstjens I, Sanchez S et al.
    Brain, Behavior, and Immunity

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Citation for GW 280264X

The citations listed below are publications that use Tocris products. Selected citations for GW 280264X include:

1 Citation: Showing 1 - 1

  1. ADAM10- and γ-secretase-dependent cleavage of the transmembrane protein PTPRT attenuates neurodegeneration in the mouse model of Alzheimer's disease.
    Authors: Li Et al.
    FASEB J  2023;37:e22734

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