GW 438014A

Name: GW 438014A
Brand: Tocris Bioscience
SKU: 4669
Price: 159 USD

Catalog #: 4669 Datasheet / COA / SDS

Discontinued Product

4669 has been discontinued.

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GW 438014A | CAS No. 469861-49-2 | NPY Receptor Agonists

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Description: NPY Y5 receptor antagonist

Chemical Name: N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate

Purity: ≥99%

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Product Details

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Neuropeptide (NPY) Y₅ receptor antagonist (IC₅₀ = 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.

Technical Data

M.Wt:

437.51

Formula:

C₂₂H₁₉N₃O.CH₃SO₃H

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

469861-49-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from GlaxoSmithKline.

Background References

Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y₅ receptor antagonist.
Daniels et al.
Regul.Pept., 2002;106:47
Neuropeptide Y Y₅ receptors inhibit kindling acquisition in rats.
Benmaamar et al.
Regul.Pept., 2005;125:79

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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