GW 441756
Chemical Name: 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
Purity: ≥99%
Biological Activity
GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration.
Landowski L, Pavez M, Brown L, Gasperini R, Taylor B, West A, Foa L
J Biol Chem, 2016;291(3):1092-102. -
Synthesis, anticancer, and docking studies of salicyl-hydrazone analogues: A novel series of small potent tropomyosin receptor kinase A inhibitors
Dong-Ung Lee
Bioorg. Med. Chem., 2016;0(0):. -
Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles.
Wood et al.
Bioorg.Med.Chem.Lett., 2004;14:953
Product Datasheets
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Citations for GW 441756
The citations listed below are publications that use Tocris products. Selected citations for GW 441756 include:
5 Citations: Showing 1 - 5
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Granulocyte-macrophage colony-stimulating factor receptor expression in clinical pain disorder tissues and role in neuronal sensitization.
Authors: Donatien Et al.
Pain Rep 2018;3:e676
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Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Authors: Rees Et al.
Oncotarget 2016;12:109
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Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells.
Authors: Lawn Et al.
Nat Chem Biol 2015;290:3814
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Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.
Authors: Edwards Et al.
J Natl Cancer Inst 2011;103:1162
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Cellular assays for high-throughput screening for modulators of Trk receptor tyrosine kinases.
Authors: Wang Et al.
Curr Chem Genomics 2008;1:27
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