GW 788388

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor
   K Oh-Oka, Y Kojima, K Uchida, K Yoda, K Ishimaru, S Nakajima, J Hemmi, H Kano, Y Fujii-Kuri, R Katoh, H Ito, A Nakao
   Cell Mol Gastroenterol Hepatol, 2017;4(1):135-151.
2. RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression.
   Jajosky A, Coad J, Vos J, Martin K, Senft J, Wenger S, Gibson L
   Stem Cells Transl Med, 2014;3(7):836-48.
3. Targeted inhibition of AVNreceptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction.
   Tan et al.
   Am.J.Physiol.Heart Circ.Physiol., 2010;298:H1415
4. The essential role of fibroblasts in esophageal squamous carcinoma-induced angiogenesis.
   Noma et al.
   Gastroenterology, 2008;134:1981
5. Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-β type I receptor inhibitor.
   Gellibert et al.
   J.Med.Chem., 2006;49:2210
6. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.
   Petersen et al.
   Kidney Int., 2008;73:705

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