H10
Discontinued Product
Chemical Name: 3-(N-(2-(4-(2-(4-((3-Carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid
Purity: ≥98%
Biological Activity
H10 is a PARP14 inhibitor (IC50 = 490 nM). Exhibits ~ 24- and 18-fold selectivity for PARP14 over PARP1 and TNKS1, respectively. Binds both the nicotinamide and adenine sites on PARP14. Inhibits PARP14 and induces apoptosis in HepG2 and RPMI-8226 in cancer cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small molecule microarray based discovery of PARP14 inhibitors.
Peng et al.
Angew.Chem.Int.Ed.Engl., 2017;56:248
Product Datasheets
Citation for H10
The citations listed below are publications that use Tocris products. Selected citations for H10 include:
1 Citation: Showing 1 - 1
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The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1.
Authors: George-Lucian Et al.
Nat Commun 2022;13:5063
FAQs
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