Haloperidol hydrochloride
Chemical Name: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
Purity: ≥98%
Biological Activity
Haloperidol hydrochloride is a dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2, D3, D4, D1 and D5 receptors respectively). Subtype-selective NMDA antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis.
Beresford and Ward
Drugs, 1987;33:31 -
Inhibition of N-MthD.-aspartate receptors by haloperidol: development and pharmacological characterization in native and recombinant receptors.
Lynch and Gallagher
J.Pharmacol.Exp.Ther., 1996;279:154 -
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264 -
Subtype-selective inhibition of N-MthD.-aspartate receptors by halope.
IIyin et al.
Mol.Pharmacol., 1996;50:1541 -
A SARS-CoV-2 protein-protein interaction map reveals drug targets and drug repurposing.
Gordon et al.
Nature, 2020;583:459
Product Datasheets
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Citations for Haloperidol hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Haloperidol hydrochloride include:
9 Citations: Showing 1 - 9
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Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs.
Authors: Joshi and Panicker
Eneuro 2019;5
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Theσ-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands.
Authors: Mishra Et al.
Brain Res 2015;466:263
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Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
J Biomol Screen 2015;40:766
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Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
Authors: Canfrán-Duque Et al.
Biochem J 2015;10:e0141829
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Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression.
Authors: Kim Et al.
Biochem Biophys Res Commun 2012;426:177
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HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Authors: Kurita Et al.
Nat Neurosci 2012;15:1245
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The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein.
Authors: Watson Et al.
Neuropsychopharmacology 2012;1436:111
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Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk.
Authors: Oliver and Davies
Hum Mol Genet 2009;18:4576
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Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments.
Authors: Balu Et al.
Brain Res 2008;1211:37
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