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HER2 PROTAC® CH7C4

Catalog #: 7886 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7886/5
HER2 PROTAC® CH7C4 | Active Degraders
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Description: Potent and selective HER2 targeting Degrader (PROTAC®)

Chemical Name: 5-((7-(4-(3-((4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperazin-1-yl)heptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Purity: ≥98%

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Biological Activity

HER2 PROTAC® CH7C4 is a potent and selective HER2 (also called ErbB-2) targeting Degrader (PROTAC®) (DC50 = 69 nM; Dmax = 96%). Inhibits BT-474 cell proliferation (IC50 = 47 nM) and xenograft growth. Comprises a Tucatinib (Cat. No. 7640) analog, joined by a linker to a CRBN E3 ligase ligand.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
910.05
Formula:
C49H55N11O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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