HER2 PROTAC® CH7C4
Chemical Name: 5-((7-(4-(3-((4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperazin-1-yl)heptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity: ≥98%
Biological Activity
HER2 PROTAC® CH7C4 is a potent and selective HER2 (also called ErbB-2) targeting Degrader (PROTAC®) (DC50 = 69 nM; Dmax = 96%). Inhibits BT-474 cell proliferation (IC50 = 47 nM) and xenograft growth. Comprises a Tucatinib (Cat. No. 7640) analog, joined by a linker to a CRBN E3 ligase ligand.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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