Home / p53 Activators / HLI 373

HLI 373

Catalog #: 3503 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3503/10
3503/50
HLI 373 | CAS No. 1782531-99-0 | p53 Activators
1 Image
Description: Hdm2 inhibitor; activates p53-dependent transcription

Chemical Name: 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride

Purity: ≥99%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.

Technical Data

M.Wt:
414.33
Formula:
C18H23N5O2.2HCl
Solubility:
Soluble to 100 mM in water and to 10 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1782531-99-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification
    M Tsuru, A Ono, H Umeyama, M Takeuchi, K Nagata
    PLoS ONE, 2018;13(5):e0196204.
  2. Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
    Kitagaki et al.
    Mol.Cancer Ther., 2008;7:2445
  3. Targeting the ubiquitin-proteasome system for cancer therapy.
    Yang et al.
    Cancer Sci., 2009;100:24

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for HLI 373

There are currently no reviews for this product. Be the first to review HLI 373 and earn rewards!

Have you used HLI 373?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.