Home / Melanocortin Receptor Antagonists / HS 014

HS 014

Catalog #: 1831
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1831/1
HS 014
1 Image
Description: Selective MC4 receptor antagonist

Purity: ≥95%

Product Details
Citations (1)
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Biological Activity

HS 014 is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.

Technical Data

M.Wt:
1563.77
Formula:
C71H94N20O17S2
Sequence:
CEHXRWGCPPKD

(Modifications: Cys-1 = N-terminal Ac, X = D-2-Nal, Asp-12 = C-terminal amide, Disulfide bridge: 1-8)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
207678-81-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Central amygdala circuits mediate hyperalgesia in alcohol-dependent rats
    EM Avegno, TD Lobell, CA Itoga, BB Baynes, AM Whitaker, MM Weera, S Edwards, JW Middleton, NW Gilpin
    J. Neurosci., 2018;0(0):.
  2. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test.
    Bellasio et al.
    Eur.J.Pharmacol., 2003;482:127
  3. Discovery of novel melanocortin4 receptor selective MSH analogues.
    Schioth et al.
    Br.J.Pharmacol., 1998;124:75
  4. Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration.
    Whitaker and Reye
    Neuropharmacology, 2008;54:509

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Citation for HS 014

The citations listed below are publications that use Tocris products. Selected citations for HS 014 include:

1 Citation: Showing 1 - 1

  1. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
    Authors: Panaro Et al.
    PLoS One  2014;20:1018

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