HS 024
Purity: ≥95%
Biological Activity
HS 024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.Technical Data
(Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge: 1-9)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.
Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T
PLoS ONE, 2015;10(4):e0123232. -
Melanocortin receptor agonist transiently increases oxygen consumption in rats.
Jonsson et al.
Neuroreport, 2001;12:3703 -
Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats.
Jonsson et al.
J.Endocrinol., 2002;173:517 -
Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo.
Kask et al.
Endocrinology, 1998;139:5006
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for HS 024
The citations listed below are publications that use Tocris products. Selected citations for HS 024 include:
2 Citations: Showing 1 - 2
-
Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.
Authors: Nepomuceno Et al.
Front Pharmacol 2018;9:157
-
Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5.
Authors: Simamura Et al.
J Neurochem 2015;10:e0123232
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsReviews for HS 024
There are currently no reviews for this product. Be the first to review HS 024 and earn rewards!
Have you used HS 024?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
