Human Activin RIIA APC-conjugated Antibody
Human Activin RIIA APC-conjugated Antibody Summary
Ala20-Pro134
Accession # P27037
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Activin RIIA in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human Activin RIIA APC-conjugated Monoclonal Antibody (Catalog # FAB340A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Activin RIIA
Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine‑threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR-I(A), ActR-IB, ActR-II(A) and ActR-IIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different high-affinities to the various type II isoforms. Type I activin receptors do not bind directly to activin, but will associate with the type II receptor-activin complex and initiate signal transduction. Besides the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities. ActR-I can also bind and form signaling complexes with the BMP-2/7-bound BMPR-II. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists.
- Attisano, L. et al. (1996) Mol. and Cell. Biol. 16:1066.
- Woodruff, T.K. (1998) Biochem. Pharmacology, 55:953.
Product Datasheets
Citations for Human Activin RIIA APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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ActivinA: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells
Authors: F Portale, G Cricrì, S Bresolin, M Lupi, S Gaspari, D Silvestri, B Russo, N Marino, P Ubezio, F Pagni, P Vergani, G Te Kronnie, MG Valsecchi, F Locatelli, C Rizzari, A Biondi, E Dander, G D'Amico
Haematologica, 2018-09-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Activin A induces apoptosis of mouse myeloma cells via the mitochondrial pathway
Authors: Yuanyi Zhang, Yan Qi, Yang Zhao, Hongyan Sun, Jingyan Ge, Zhonghui Liu
Oncology Letters
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