Human alpha-Synuclein Antibody

Catalog #: MAB1338
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB1338
MAB1338-SP

Product Details

Citations (2)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human alpha-Synuclein Antibody Summary

Species Reactivity

Human

Specificity

Detects human alpha -Synuclein in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG₁ Clone # 189105

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

E. coli-derived recombinant human alpha -Synuclein
Met1-Ala140
Accession # P37840

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human alpha -Synuclein

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: alpha-Synuclein

alpha -Synuclein is a cytoplasmic protein that is predominantly expressed in the central nervous system. It is a precursor of a minor peptide found in amyloid deposition that is a hallmark of Alzheimer's disease. Defects in alpha -Synuclein are associated with familial Parkinson's disease.

Entrez Gene IDs

6622 (Human); 20617 (Mouse); 29219 (Rat); 641350 (Porcine); 282857 (Bovine)

Alternate Names

alpha-Synuclein; I+/--synuclein; MGC110988; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; SNCA; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); Synuclein-alpha; truncated alpha synuclein

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human alpha-Synuclein Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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In Situ Proximity Ligation Assay Reveals Co-Localization of Alpha-Synuclein and SNARE Proteins in Murine Primary Neurons
Authors: Leire Almandoz-Gil, Emma Persson, Veronica Lindström, Martin Ingelsson, Anna Erlandsson, Joakim Bergström
Frontiers in Neurology
Extensive uptake of ?-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
Authors: V Lindström, G Gustafsson, LH Sanders, EH Howlett, J Sigvardson, A Kasrayan, M Ingelsson, J Bergström, A Erlandsson
Mol. Cell. Neurosci., 2017-04-24;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: ELISA Development (Capture)