Human Aminopeptidase N/CD13 APC-conjugated Antibody
Human Aminopeptidase N/CD13 APC-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Aminopeptidase N/CD13 in U937 human cell line by Flow Cytometry. U937 human cell line was stained with Mouse Anti-Human Aminopeptidase N/CD13 APC-conjugated Monoclonal Antibody (Catalog # FAB8284A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of Aminopeptidase N/CD13 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human Aminopeptidase N/CD13 APC-conjugated Monoclonal Antibody (Catalog # FAB8284A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Aminopeptidase N/CD13 Specificity is Shown by Flow Cytometry in Knockout Cell Line. Aminopeptidase N/CD13 knockout U937 human lymphoma cell line was stained with APC-conjugated Mouse Anti-Human Aminopeptidase N/CD13 Monoclonal Antibody (Catalog # FAB8284A, filled histogram) or isotype control antibody (IC002A, open histogram). No staining in the Aminopeptidase N/CD13 knockout U937 cell line was observed. Staining was performed using our Staining Membrane-associated Proteins protocol.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Aminopeptidase N/CD13
The human ANPEP gene encodes Aminopeptidase N (APN), which is also known as Microsomal Aminopeptidase, Alanyl Aminopeptidase, Aminopeptidase M, CD13, or Membrane Protein p161 (1-3). The deduced amino acid sequence of human APN consists of a short cytoplasmic tail (residues 2 to 8), a transmembrane region (residue 9 to 32), a Ser/Thr rich region and a zinc metalloprotease domain (residues 69 to 966). The amino acid sequence of human APN is 78% and 77% identical to that of rat and mouse, respectively. Widely expressed in many cells, tissues and species, APN cleaves the N-terminal amino acids from bioactive peptides, leading to their inactivation or degradation. The roles of APN in many fields, such as neuroscience, hematopoeitic cells, immune system, angiogenesis, cancer and viral infection, have been reviewed (3).
- Olsen, J. et al. (1988) FEBS Lett. 238:307.
- Look, A.T. et al. (1989) J. Clin. Invest. 83:1299.
- Turner, A.J. (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, et al.) pp. 289, Academic Press, San Diego.
Product Datasheets
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