Human Angiostatin Kringle 1-3 Antibody

Catalog #: MAB926
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB926
MAB926-SP

All Angiostatin Antibodies

Product Details

Citations (2)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Angiostatin Kringle 1-3 Antibody Summary

Species Reactivity

Human

Specificity

Detects human Angiostatin Kringle 1-3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody also detects plasminogen but does not cross-react with recombinant mouse Angiostatin.

Source

Monoclonal Mouse IgG_2A Clone # 79735

Purification

Protein A or G purified from ascites

Immunogen

E. coli-derived recombinant human Angiostatin Kringle 1-3
Val98-Ser358 (Cys88Ser, Cys316Ser)
Accession # P00747

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human Angiostatin Kringle 1-3

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Angiostatin

Plasminogen is the precursor of plasmin, an active serine protease that dissolves the fibrin of blood clots and acts in many other processes such as embryonic development, tissue remodeling, inflammation and tumor invasion. Synthesized in the kidney, plasminogen is found in plasma and many extracellular fluids. Activated by u- or t-plasminogen activator, the single-chain plasminogen is converted to plasmin that consists of a disulfide bond-linked heavy chain A and light chain B. Heavy chain A contains 5 kringle domains and light chain B corresponds to the serine protease domain. A fragment consisting of the first 4 kringle domains has been named angiostatin, a novel angiogenesis inhibitor.

Entrez Gene IDs

5340 (Human); 18815 (Mouse)

Alternate Names

Angiostatin; HAE4

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human Angiostatin Kringle 1-3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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