Human beta-2 Adrenergic R/ADRB2 (NP_000015) VersaClone cDNA

Catalog #: RDC0631 Datasheet / COA / SDS

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RDC0631

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Human beta-2 Adrenergic R/ADRB2 (NP_000015) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: beta-2 Adrenergic R/ADRB2

ADRB2 is a member of the G protein-coupled receptor superfamily that is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. ADRB2 binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by ADRB2. Different polymorphic forms, point mutations, and/or downregulation of ADRB2 are associated with nocturnal asthma, obesity and type 2 diabetes.

Long Name

Beta-2 Adrenergic Receptor

Entrez Gene IDs

154 (Human); 11555 (Mouse); 24176 (Rat)

Alternate Names

ADRB2; ADRB2R; ADRBR; adrenergic, beta-2-, receptor, surface; B2AR; B2ARADRB2R; BAR; beta-2 Adrenergic R; beta-2 adrenergic receptor; beta2 AdrenergicR; beta-2 AdrenergicR; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; BETA2AR; catecholamine receptor