Human beta-Glucuronidase/GUSB (NP_000172.2) VersaClone cDNA

Human beta-Glucuronidase/GUSB (NP_000172.2) VersaClone cDNA Summary

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Background: beta-Glucuronidase/GUSB

Human beta-Glucuronidase (EC 3.2.1.31) encoded by the GUSB gene is a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans that include heparan sulfate, chondroitin sulfate and hyaluronan. The enzyme is only active on the glucuronic acid of the non-reducing end. The native protein has been reported as a tetrameric glycoprotein composed of identical subunits. Mutations in the GUSB gene are linked to mucopolysaccharidosis type VII. Accumulation of partially degraded glycosaminoglycans, with glucuronic acid residues at the non-reducing termini, are usually found in the lysosomes of patients with the disease. It has also been reported that this enzyme may contribute to the depletion of chondroitin from cartilage and thereby facilitate the damage of joints in rheumatoid arthritis.

Related Research Areas

• Glycobiology-related Enzymes
• Lysosomal Enzymes
• Platelet Lysosome Molecules
• Proteoglycan Regulators
• Proteoglycans and Regulators
• Search Bioprocessing Enzymes
• Search Glycobiology-related Enzymes