Human BMPR-II Antibody

Catalog #: MAB811
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB811-SP
MAB811-500
MAB811-100

All BMPR-II Antibodies

Product Details

Citations (5)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human BMPR-II Antibody Summary

Species Reactivity

Human

Specificity

Detects human BMPR-II in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross‑react with recombinant human (rh) BMP R-IA or rhBMPR-IB.

Source

Monoclonal Mouse IgG_2B Clone # 73805

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant human BMPR-II
Ala26-Ile151
Accession # Q13873

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human BMPR-II Fc Chimera (Catalog # 811-BR)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: BMPR-II

Like other members of the TGF-beta superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signl transduction. BMP receptor II (BMPR-II) is one of the five mammalian type II receptors (including TGF-beta R-II, ActR-II, ActR-IIB, BMPR-II and MISR-II) for the TGF-beta superfamily ligands. The type II receptors for TGF-beta and activin bind ligands with high affinity by itself. In contrast, BMPR-II binds BMP-2, BMP-4 and BMP-7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPR-II mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPR-II are highly conserved sharing 97% sequence identity.

References

Rosenzweig, B.L. et al. (1995) Proc. Natl. Acad. Sci. USA 92:7632.
Beppu, H. et al. (1997) Biochem. Biophys. Res. Commun. 235:499.
Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49.

Long Name

Bone Morphogenetic Protein Receptor II

Entrez Gene IDs

659 (Human); 12168 (Mouse)

Alternate Names

BMP type II receptor; BMP type-2 receptor; BMPR2; BMPR-2; BMPR3; BMPRII; BMPR-II; BMPR-IIprimary pulmonary hypertension 1; Bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); BRK-3; EC 2.7.11; EC 2.7.11.30; FLJ41585; FLJ76945; PPH1BMR2; T-ALK; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human BMPR-II Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant
Authors: V Veschi, LR Mangiapane, A Nicotra, S Di Franco, E Scavo, T Apuzzo, DS Sardina, M Fiori, A Benfante, ML Colorito, G Cocorullo, F Giuliante, C Cipolla, G Pistone, MR Bongiorno, A Rizzo, CM Tate, X Wu, S Rowlinson, LF Stancato, M Todaro, R De Maria, G Stassi
Oncogene, 2019-10-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: ICC
TNF? drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
Authors: LA Hurst, BJ Dunmore, L Long, A Crosby, R Al-Lamki, J Deighton, M Southwood, X Yang, MZ Nikolic, B Herrera, GJ Inman, JR Bradley, AA Rana, PD Upton, NW Morrell
Nat Commun, 2017-01-13;8(0):14079.
Species: Human
Sample Types: Cell Culture Supernates, Cell Lysates
Applications: ELISA Development, Immunoprecipitation
Casein kinase II contributes to the synergistic effects of BMP7 and BDNF on Smad 1/5/8 phosphorylation in septal neurons under hypoglycemic stress.
Authors: Chaverneff F, Barrett J
J. Neurochem., 2009-02-13;109(3):733-43.
Species: Rat
Sample Types: Whole Cells
Applications: ICC
A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
Authors: Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY
J. Mol. Biol., 2008-07-02;381(4):1025-39.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Development
Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism.
Authors: Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller ET
Cancer Res., 2005-09-15;65(18):8274-85.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot